Neural systems underlying RDoC social constructs: An activation likelihood estimation meta-analysis.

Neuroscientists have sought to identify the underlying neural systems supporting social processing that allow interaction and communication, forming social relationships, and navigating the social world. Through the use of NIMH's Research Domain Criteria (RDoC) framework, we evaluated consensus among studies that examined brain activity during social tasks to elucidate regions comprising the "social brain". We examined convergence across tasks corresponding to the four RDoC social constructs, including Affiliation and Attachment, Social Communication, Perception and Understanding of Self, and Perception and Understanding of Others. We performed a series of coordinate-based meta-analyses using the activation likelihood estimate (ALE) method. Meta-analysis was performed on whole-brain coordinates reported from 864 fMRI contrasts using the NiMARE Python package, revealing convergence in medial prefrontal cortex, anterior cingulate cortex, posterior cingulate cortex, temporoparietal junction, bilateral insula, amygdala, fusiform gyrus, precuneus, and thalamus. Additionally, four separate RDoC-based meta-analyses revealed differential convergence associated with the four social constructs. These outcomes highlight the neural support underlying these social constructs and inform future research on alterations among neurotypical and atypical populations.

Extended functional connectivity of convergent structural alterations among individuals with PTSD: a neuroimaging meta-analysis.

BACKGROUND: Post-traumatic stress disorder (PTSD) is a debilitating disorder defined by the onset of intrusive, avoidant, negative cognitive or affective, and/or hyperarousal symptoms after witnessing or experiencing a traumatic event. Previous voxel-based morphometry studies have provided insight into structural brain alterations associated with PTSD with notable heterogeneity across these studies. Furthermore, how structural alterations may be associated with brain function, as measured by task-free and task-based functional connectivity, remains to be elucidated. METHODS: Using emergent meta-analytic techniques, we sought to first identify a consensus of structural alterations in PTSD using the anatomical likelihood estimation (ALE) approach. Next, we generated functional profiles of identified convergent structural regions utilizing resting-state functional connectivity (rsFC) and meta-analytic co-activation modeling (MACM) methods. Finally, we performed functional decoding to examine mental functions associated with our ALE, rsFC, and MACM brain characterizations. RESULTS: We observed convergent structural alterations in a single region located in the medial prefrontal cortex. The resultant rsFC and MACM maps identified functional connectivity across a widespread, whole-brain network that included frontoparietal and limbic regions. Functional decoding revealed overlapping associations with attention, memory, and emotion processes. CONCLUSIONS: Consensus-based functional connectivity was observed in regions of the default mode, salience, and central executive networks, which play a role in the tripartite model of psychopathology. Taken together, these findings have important implications for understanding the neurobiological mechanisms associated with PTSD.

The Ethnic Identity Scale: Affirmation, really?

OBJECTIVE: The Ethnic Identity Scale (EIS) was developed to distinguish between process and content components of ethnic-racial identity (ERI). However, the affirmation subscale is composed entirely of negatively worded items, measuring negative feelings about one's ethnic-racial group, rather than positive feelings as widely conceptualized. Addressing this gap, the present study examined the psychometric validity of a revised EIS with positively and negatively worded items to determine whether affirmation is best represented as a unidimensional construct, a bidimensional construct, or a combination of the two. METHOD: The sample consisted of 280 college students (75.5% female; Mage = 20.95 years; SD = 1.98 years). The largest ethnic-racial group consisted of Black or African Americans (68.2%), followed by Asian/Asian Americans (12.1%), Hispanic/Latinos (9.6%), and other ethnic-racial groups (10%). RESULTS: Confirmatory factor analysis provided evidence for both unidimensionality and multidimensionality. Indeed, although positively worded and negatively worded items of "affirmation" loaded onto a general factor representing affirmation, there was still a significant amount of variance captured by the negative ERI affect specific factor, indicating the presence of multidimensionality. In addition, results indicated that negative ERI affect, over and above the general ERI affirmation factor, predicted psychosocial functioning. CONCLUSIONS: The present study expands our understanding of the multidimensionality of ERI, highlighting the need for examination of how we measure ERI affect at the very least, and possibly how we conceptualize it within the broader ERI literature. (PsycInfo Database Record (c) 2022 APA, all rights reserved).